Bone mineral density and its influencing factors in Chinese children with spinal muscular atrophy types 2 and 3

Abstract Background Patients with spinal muscular atrophy (SMA) are at risk of decreased bone mineral density (BMD). The health status Chinese patients SMA has been poorly studied. We aimed to evaluate the BMD children types 2 and 3 in mainland China investigate its influencing factors. Methods Forty a mean age 5.5 years affected by ( n = 22 18, respectively) were enrolled between September 2017 May 2019. Total body less head (TBLH) BMD, lumbar spine (LS) composition measured using dual-energy X-ray absorptiometry (DXA). Serum metabolism markers complete radiographs assessed. utilized linear regression model explore correlations related Results A total 67.5% (27/40) diagnosed low 2.5% (1/40) osteoporosis. TBLH LS Z-scores type significantly lower than those 3. Both tended increase change subtypes from 2a-3b. Vitamin D insufficiency deficiency found 37.5% (15/40) patients. Ca, phosphorus (P), alkaline phosphatase (ALP) parathormone (PTH) levels normal. There no significant differences among four terms all serum markers. Phenotype was associated Z-scores, PTH Z-scores. Conclusions Low osteoporosis highly prevalent level might be factors BMD. Regular monitoring DXA scan taking active interventions aim different important.